FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pde1cc04487
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General Information
Symbol
Dmel\Pde1cc04487
Species
D. melanogaster
Name
FlyBase ID
FBal0160037
Feature type
allele
Associated gene
Dmel\Pde1c
Associated Insertion(s)
PBac{PB}Pde1cc04487
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Morton et al., 2010)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Pde1cc04487
Cytology
Description

Insertion in an intron.

(Morton et al., 2010)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  nervous system disease
      modeled by AtpĪ±CJ5
      (Talsma et al., 2014)
      exacerbates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Al-Ramahi et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males copulate significantly less frequently than their heterozygous siblings and than wild-type controls. Those males that do copulate take significantly longer to begin copulation than control males. Homozygous males spend a similar fraction of time engaged in courtship behaviour as control males. Some matings do result in sperm being successfully transferred to the female. 72 hours after mating, sperm are rarely detected in the reproductive system of females mated to homozygous males, suggesting that the sperm have either been eliminated or degraded.

      (Morton et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Pde1cc04487 is partially rescued by Pde1cRC.UAS/Scer\GAL4Pde1c.RC

      (Morton et al., 2010)

      Pde1cc04487 is partially rescued by Scer\GAL4elav.PU/Pde1cRC.UAS

      (Morton et al., 2010)
      Comments

      Pde1cc04487 males which are expressing Pde1cRC.Scer\UAS under the control of Scer\GAL4Pde1c.RC are partially fertile, with more than 50% of male-female pairs producing progeny. The number of progeny resulting from successful matings is similar to control matings.

      Pde1cc04487 males which are expressing Pde1cRC.Scer\UAS under the control of Scer\GAL4elav.PU are partially fertile, with less than 25% of male-female pairs producing progeny.

      The copulation defects seen in Pde1cc04487 males are completely rescued by expression of Pde1cRC.Scer\UAS under the control of either Scer\GAL4Pde1c.RC or Scer\GAL4elav.PU.

      (Morton et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the insertion can revert the male sterile phenotype.

      (Morton et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pde1cc04487
      (Al-Ramahi et al., 2018, Morton et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)