FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Or47bUAS.Tag:MYC
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General Information
Symbol
Dmel\Or47bUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0160099
Feature type
allele
Associated gene
Dmel\Or47b
Associated Insertion(s)
Carried in Construct
P{UAS-Or47b.MYC}
Also Known As
UAS-Or47b
Key Links
Transgenic product class
wild_type
(Hallem et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hallem et al., 2004)
Mutagen
in vitro construct
(Hallem et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Or47b.MYC}
Cytology
Description

UAS sequences drive expression of Or47b tagged with Tag:MYC

(Hallem et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Or47b
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ab3A neurons expressing Or47bScer\UAS.T:Hsap\MYC in Df(2L)dp-79b/Dp(2;2)dppd21 (Δhalo) flies do not respond to any fruit odours or pure odorants above a rate of 50 spikes/s. However, these neurons show inhibitory responses to 34% of 110 tested odorants.

      (Hallem and Carlson, 2006)

      When Or47bScer\UAS.T:Hsap\MYC is driven by Scer\GAL4Or22a.8197 in Df(2L)dp-79b/Dp(2;2)dppd21 (Δhalo) flies, mutant animals do not exhibit a strong response to exposure to ethyl acetate, pentyl acetate, ethyl butyrate,methyl salicylate, 1-hexanol, 1-octen-3-ol, E2-hexanal,2,3-butanedione, 2-heptanone or geranyl acetate in the ab3A neuron. When Or47bScer\UAS.T:Hsap\MYC is driven by Scer\GAL4Or22a.8197 in Df(2L)dp-79b/Dp(2;2)dppd21 (Δhalo) flies, the spontaneous firing rate of the ab3A neuron is seen to be similar to the atXA neuron, the neuron that normally expresses Or47b. Inhibitory responses for the mutant ab3A neuron appear to be those expected for neurons expressing Or47b.

      (Hallem et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When Or47bScer\UAS.T:Hsap\MYC and Or22aScer\UAS.T:Hsap\MYC are co-expressed in Df(2L)dp-79b/Dp(2;2)dppd21 (Δhalo) flies (driven by Scer\GAL4Or22a.8197) both excitatory and inhibitory responses are seen, depending on the stimulus offered. Those stimuli that gave opposite responses in cells expressing the individual receptor genes, gave intermediate responses in combination.

      (Hallem et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Or47bUAS.Tag:MYC/Scer\GAL4Or47b.7.467 rescues Or47b3

      (Dweck et al., 2015)
      Comments

      Expression of Or47bScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or47b.7.467 rescues the reduced copulation success of Or47b3 mutant males toward wild-type females both under competitive (with wild-type males) and non-competitive conditions (no other males present).

      (Dweck et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Or47bScer\UAS.T:Hsap\MYC
      Or47bUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (8)