FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\KCNJ2R228Q.UAS.EGFP
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General Information
Symbol
Hsap\KCNJ2R228Q.UAS.EGFP
Species
H. sapiens
Name
FlyBase ID
FBal0160309
Feature type
allele
Associated gene
Hsap\KCNJ2
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\KCNJ2.EGFP.R228Q}
Also Known As
Kir2.1R228Q
Key Links
Transgenic product class
missense_variant
(Hardie et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hardie et al., 2004)
Mutagen
in vitro construct
(Hardie et al., 2004)
Progenitor genotype
Hsap\KCNJ2UAS.EGFP
(Hardie et al., 2004)
Carried in construct
P{UAS-Hsap\KCNJ2.EGFP.R228Q}
Cytology
Description

Construct: Amino acid replacement: R228Q.

(Hardie et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\KCNJ2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      In inaC2 photoreceptors expressing Hsap\KCNJ2R228Q.Scer\UAS.T:Avic\GFP-EGFP channels, the PIP2-sensitive current is suppressed by more than 50%, while it is only suppressed by 20% in wild-type photoreceptors. After depletion, the Hsap\KCNJ2R228Q.Scer\UAS.T:Avic\GFP-EGFP current recovers in the dark as PIP2 is resynthesised with a timecourse that is indistinguishable from controls. Similarly, the PIP2-sensitive current is suppressed by a significantly greater extent in trp9 photoreceptors than in wild-type photoreceptors.

      (Gu et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\KCNJ2R228Q.Scer\UAS.T:Avic\GFP-EGFP
      Hsap\KCNJ2R228Q.UAS.EGFP
      Kir2.1R228Q
      (Gu et al., 2005, Hardie et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)