FlyBase Allele Report: Dmel\Eaat2[e03003]

General Information

Symbol

Dmel\Eaat2^e03003

Species

D. melanogaster

Name

FlyBase ID

FBal0160570

Feature type

allele

Associated gene

Dmel\Eaat2

Associated Insertion(s)

PBac{RB}Eaat2^e03003

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{RB}Eaat2^e03003

Cytology

Description

PBac{RB}Eaat2^e03003 is inserted in exon 6 of Eaat2.

(Besson et al., 2011)

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:739,011..739,011 [-]

(Besson et al., 2011, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior

(Besson et al., 2011)

viable

(Besson et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Eaat2^e03003 appears morphologically normal and presents no locomotor or phototaxis impairments. However, taurine levels in the brain are significantly reduced compared to that of wild-type flies.

Eaat2^e03003 mutants display decreased avoidance å in the presence of a high concentration of propionic acid, compared with wild-type flies, but no modification of the avoidance response to benzaldehyde. In gustatory tests, both mutant and control flies are normally attracted to sucrose; however, Eaat2^e03003 mutants present a higher salt sensitivity, being repulsed by low and high salt concentrations.

(Besson et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions