FB2026_02 , released June 18, 2026
Allele: Dmel\Cyp303a12
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General Information
Symbol
Dmel\Cyp303a12
Species
D. melanogaster
Name
FlyBase ID
FBal0160660
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G311E.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G16295282A

    Reported nucleotide change:

    G1076A

    Amino acid change:

    G311E | Cyp303a1-PA; G311E | Cyp303a1-PB

    Reported amino acid change:

    G311E

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutant adults exhibit behavioural defects: they have difficulty in walking, are unable to fly, have held-up wings, and are uncoordinated. Mutant animals have abnormal electrophysiological responses from mechanosensory bristles. Mutants exhibit a dramatic loss in mechanoreceptor potential (MRP). Transepithelial potential (TEP) is also severely reduced, even after voltage clamping of the bristle organ. Mutant animals have significant defects in chemosensory responses. Mutant bristle organs exhibit morphological defects. In mutant socket cells, the apical membrane folds are dramatically disrupted and largely absent. In addition the shaft cell and neuron exhibit severe defects. The shaft cell fails to degenerate as normal after forming the bristle shaft. The cuticular shaft structures are normal. The neuron outer segment is also missing in mutants with only the crumpled remains of the dendritic sheath visible. Mutant larvae have a normal touch response.

    External Data
    Interactions
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    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Cyp303a12
    Name Synonyms
    Secondary FlyBase IDs
      References (1)