FB2026_03 , released September 17, 2026
Allele: Dmel\eIF2Ac00723
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General Information
Symbol
Dmel\eIF2Ac00723
Species
D. melanogaster
Name
FlyBase ID
FBal0161034
Feature type
allele
Associated gene
Dmel\eIF2A
Associated Insertion(s)
PBac{PB}eIF2Ac00723
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Lowe and Montell, 2022)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}eIF2Ac00723
Cytology
Description
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eIF2Ac00723 homozygous and eIF2Ac00723/eIF2AMI06462 and eIF2Ac00723/Df(3L)ED4978 transheterozygous males show small seminal vesicles. eIF2Ac00723/Df(3L)ED4978 transheterozygotes lack lack coiling sperm in the basal end of the testis and mature sperm in the seminal vesicle. eIF2Ac00723/eIF2AMI06462 transheterozygotes show at least one bundle of coiled sperm at the testis base.

      In eIF2Ac00723/eIF2AMI06462, eIF2Ac00723/Df(3L)ED4978 and eIF2Ac00723/Df(3L)BSC284 transheterozygous males, the testes contain fewer cystic bulges and lack waste bags, as compared to the controls. eIF2Ac00723/eIF2AMI06462 and eIF2Ac00723/Df(3L)ED4978 testes contain many disorganized spermatids that appeared to be in tangled "knots", in contrast to the highly ordered structure of controls.

      (Lowe and Montell, 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG7414c00723
      PB
      (Lowe and Montell, 2022)
      eIF2Ac00723
      Name Synonyms
      Secondary FlyBase IDs
        References (3)