FB2026_02 , released June 18, 2026
Allele: Dmel\how2455
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General Information
Symbol
Dmel\how2455
Species
D. melanogaster
Name
FlyBase ID
FBal0175648
Feature type
allele
Associated gene
Dmel\how
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kankel et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous female germline clones are normal.

      (Kankel et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      how[+]/how2455 is an enhancer of partially lethal | heat sensitive phenotype of ftz5/ftz13

      (Kankel et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      how[+]/how2455 is a suppressor of embryonic segment phenotype of ftz5/ftz13

      (Kankel et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      how2455 dominantly enhances the lethality of ftz5/ftz13 animals at 26.5oC (fewer animals survive to adulthood). This interaction is a purely zygotic effect. how2455 dominantly suppresses the segmentation defects seen in ftz5/ftz13 embryos at 27.5oC; 26.2% of the embryos have segment defects and 1.5% have at least 3 ftz-dependent segments affected.

      (Kankel et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a dominant enhancer of the lethality of ftz5/ftz13 at 26.5oC.

      (Kankel et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      how2455
      Name Synonyms
      Secondary FlyBase IDs
        References (1)