FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Top2suo2
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General Information
Symbol
Dmel\Top2suo2
Species
D. melanogaster
Name
FlyBase ID
FBal0177590
Feature type
allele
Associated gene
Dmel\Top2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bucciarelli et al., 2003)
Progenitor genotype
Cytology
Description

No mutation has been found in any Top2 protein coding exon.

(Mengoli et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      metaphase & condensed nuclear chromosome & spermatocyte

      (Bucciarelli et al., 2003)
      Detailed Description
      Statement
      Reference

      The brains of Top2suo2/Top2suo2 homozygote third instar larvae (treated with colchicine and hypotonic solution) do not show significant increase in the frequency of chromosomal aberrations compared to wild-type.

      (Mengoli et al., 2014)

      suo2 prometaphase and metaphase I figures are normal, but anaphases and telophases are characterised by the presence of chromatin bridges. As a result of these bridges, in 29% of suo2 ana-telophase I cells, all the chromosomes segregate to one pole only, giving rise to chromosome-free secondary spermatocytes. suo2 secondary spermatocytes devoid of chromosomes form a bipolar spindle that undergoes the same dynamic transformations seen in chromosome-containing spindles.

      (Bucciarelli et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated in a cytological screen of a collection of male sterile mutants.

      (Bucciarelli et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Top2suo2
      (Mengoli et al., 2014)
      suo2
      (Mengoli et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)