FlyBase Allele Report: Dmel\Tdp1[A12]

General Information

Symbol

Dmel\Tdp1^A12

Species

D. melanogaster

Name

FlyBase ID

FBal0179629

Feature type

allele

Associated gene

Dmel\Tdp1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dunlop et al., 2004)

Progenitor genotype

P{lacW}Mad^k00223

(Dunlop et al., 2004)

Cytology

Description

Imprecise excision of the P{lacW}Mad^k00223 element, resulting in a deletion of 58bp which has been partially replaced by a 35bp random sequence upstream of the gkt transcriptional start site.

(Dunlop et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | germline clone

(Dunlop et al., 2004)

lethal (with Tdp1^G85)

(Dunlop et al., 2004)

lethal (with Tdp1^k00223)

(Dunlop et al., 2004)

lethal | embryonic stage | recessive

(Dunlop et al., 2004)

lethal | larval stage | recessive

(Dunlop et al., 2004)

Phenotype Manifest In

embryonic epidermis | germline clone

(Dunlop et al., 2004)

presumptive embryonic/larval central nervous system | germline clone

(Dunlop et al., 2004)

Detailed Description

Statement

Reference

Homozygotes die at late embryonic/early larval stages. Embryos derived from females carrying homozygous germline clones show major disruption of the epidermis and central nervous system. There is an almost complete failure of normal axonal outgrowth, which is apparent from the early stages.

(Dunlop et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Tdp1^k00223

(Dunlop et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: Mad². Complements: Mad^B1. Complements: CG3347^KG05281.

(Dunlop et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tdp1^A12

gkt^A12

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close