FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nedd4C974FS
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General Information
Symbol
Dmel\Nedd4C974FS
Species
D. melanogaster
Name
FlyBase ID
FBal0182553
Feature type
allele
Associated gene
Dmel\Nedd4
Associated Insertion(s)
P{GSV6}GS13178
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sakata, 2004)
Progenitor genotype
P{GSV6}GS13178
(Sakata, 2004)
Associated Insertion(s)
P{GSV6}GS13178
Cytology
Description

Frameshift at position C974.

(Sakata et al., 2004)

Amino acid alteration. In addition, the P{GSV6}Nedd4GS13178 insertion is still present on the chromosome.

(Sakata, 2004)
Allele components
Component
Use(s)
Inserted element
P{GSV6}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_alteration
3L:17,544,485..17,545,508 [+]
Comment:

Frameshift at codon C974. Codon C974 spans an intron. The P{GSV6}Nedd4GS13178 insertion is still present on the chromosome.

(Sakata et al., 2004)
transposable_element_insertion_site
3L:17,529,817..17,529,817
(Sakata, 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Nedd4C974FS under the control of Scer\GAL4ptc-559.1 results in a loss of the anterior crossvein in the wing. The wing phenotype caused by expression of Nedd4GS13178 under the control of Scer\GAL4ptc-559.1 is suppressed by Nedd4C974FS.

      (Sakata, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Nedd4C974FS, Scer\GAL4ptc-559.1, dxUAS.cMa has visible phenotype

      (Sakata, 2004)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Nedd4C974FS, Scer\GAL4ptc-559.1, dxUAS.cMa has wing phenotype

      (Sakata, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Nedd4C974FS enhances the wing phenotype caused by expression of dxScer\UAS.cMa under the control of Scer\GAL4ptc-559.1; ectopic wing margin is formed.

      (Sakata, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a revertant of the larval lethality caused by expression of Nedd4GS13178 under the control of Scer\GAL4da.G32.

      (Sakata, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EP-Nedd4C974FS
      (Jaekel and Klein, 2006)
      EP-Nedd4C974FS
      (Jaekel and Klein, 2006)
      Nedd4C974FS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)