FB2026_03 , released September 17, 2026
Allele: Dsim\Hmr+t8.6
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General Information
Symbol
Dsim\Hmr+t8.6
Species
D. simulans
Name
FlyBase ID
FBal0184055
Feature type
allele
Associated gene
Dsim\Hmr
Associated Insertion(s)
Carried in Construct
P{Dsim\Hmr+t8.6}
Transgenic product class
genomic_DNA
(Barbash et al., 2004)
wild_type
(Barbash et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Barbash et al., 2004)
wild_type
(Barbash et al., 2004)
Mutagen
in vitro construct
(Barbash et al., 2004)
Progenitor genotype
Carried in construct
P{Dsim\Hmr+t8.6}
Cytology
Description

Approximately 8.6kb NotI/XbaI genomic fragment that extends from approximately 2.8kb 5' of Dsim\Hmr to approximately 1.05kb 3' of Dsim\Hmr. This fragment also contains the complete predicted coding region of Dsim\CG2124.

(Barbash et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
Dsim\Hmr
Encoded product / tool
Dsim\Hmr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hmr2 suppresses hybrid male lethality of hybrid sons of crosses between D.melanogaster females and D.simulans males. This hybrid rescue is not suppressed if the hybrids also carry Dsim\Hmr+t8.6 or Dmau\Hmr+t9.4.

      Hmr1 suppresses hybrid male lethality of hybrid sons of crosses between D.melanogaster females and D.mauritiana males. This hybrid rescue is not suppressed if the hybrids also carry Dsim\Hmr+t8.6 or Dmau\Hmr+t9.4.

      The sterility of hybrid daughters of crosses between D.melanogaster females and D.simulans males is suppressed by Hmr2. This Hmr2-dependent rescue of hybrid female sterility is not affected if the hybrids also carry Dsim\Hmr+t8.6.

      (Barbash et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In(1)AB suppresses hybrid male lethality of hybrid sons of crosses between D.melanogaster females and D.simulans males. This hybrid rescue is not suppressed if the hybrids also carry Dsim\Hmr+t8.6 or Dmau\Hmr+t9.4. Hmr1 suppresses hybrid male lethality of hybrid sons of crosses between D.melanogaster females and D.mauritiana males. This hybrid rescue is not suppressed if the hybrids also carry Dsim\Hmr+t8.6 or Dmau\Hmr+t9.4. The sterility of hybrid daughters of crosses between D.melanogaster females and D.simulans males is suppressed by In(1)AB. This In(1)AB-dependent rescue of hybrid female sterility is not affected if the hybrids also carry Dsim\Hmr+t8.6.

      (Barbash et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference

      The reduced viability of HmrDf/HmrDf females that is seen at 27[o]C is not rescued by Dsim\Hmr+t8.6, while the reduced fertility phenotype of HmrDf/HmrDf females is partially complemented by Dsim\Hmr+t8.6.

      (Aruna et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dsim\Hmr+t8.6
      Name Synonyms
      Secondary FlyBase IDs
        References (3)