FB2026_03 , released September 17, 2026
Allele: Dmel\Sld5c01719
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General Information
Symbol
Dmel\Sld5c01719
Species
D. melanogaster
Name
FlyBase ID
FBal0187187
Feature type
allele
Associated gene
Dmel\Sld5
Associated Insertion(s)
PBac{PB}Sld5c01719
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Sld5c01719
Cytology
Description
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Sld5c01719 mutants arrest at late embryo/first instar larval stage.

      While wild-type mitotic figures appear normal, numerous types of mitotic defects are observed in wandering third instar larval brains of heterozygous Sld5A462 mutants. All of the metaphase chromosomes observed in the heterozygous Sld5c01719 mutant background are characterised by defects in condensation as evidenced by longer than normal chromosomes. In addition, a variety of mitotic aberrations are observed including polycentric chromosomes, chromosome breakage, and telomere fusions. Mitotic index measurements for these tissues demonstrate significant M-phase delays in the mutant compared with wild-type.

      (Gouge and Christensen, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Sld5c01719 is rescued by Sld5Tag:MYC

      (Gouge and Christensen, 2010)
      Comments

      The lethality associated with homozygous Sld5c01719 is rescued by Sld5T:Hsap\MYC.

      (Gouge and Christensen, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG14549c01719
      Sld5c010719
      (Gouge and Christensen, 2010)
      Sld5c01719
      Name Synonyms
      Secondary FlyBase IDs
        References (2)