FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\RhoGAP93BUAS.cHa
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General Information
Symbol
Dmel\RhoGAP93BUAS.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0189844
Feature type
allele
Associated gene
Dmel\RhoGAP93B
Associated Insertion(s)
Carried in Construct
P{UAS-CrGAP.H}
Key Links
Transgenic product class
inframe_deletion
(Hu et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Hu et al., 2005)
Mutagen
in vitro construct
(Hu, 2005, Hu et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-CrGAP.H}
Cytology
Description

UASt sequences drive expression of RhoGAP93B missing the first 22 amino acids of the gene.

(Hu et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
RhoGAP93B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When expressed at high level (two copies of RhoGAP93BScer\UAS.cHa and two copies of Scer\GAL4elav.PLu, or three copies of RhoGAP93BScer\UAS.cHa and one of Scer\GAL4elav.PLu) a range of defects are observed. Multiple ectopic crosses of the longitudinal axons at the midline are seen, and the whole axon scaffold is altered, causing a thickening of the commissures and thinning of longitudinal connectives. Some embryos show an axon outgrowth defect, in which multiple longitudinal axon pathways fail to extend.

      (Hu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When RhoGAP93BScer\UAS.cHa is driven by RhoGAP93BScer\UAS.cHa in a sli1/+, robo5/+ background, the axon scaffold of the ventral midline is severely disrupted. The ectopic crossing defect see at low frequency in sli1/+, robo5 embryos is enhanced.

      (Hu et al., 2005)

      When RhoGAP93BScer\UAS.cHa is driven by Scer\GAL4elav.PLu in a fraunspecified background no midline crossing defects are seen. When RhoGAP93BScer\UAS.cHa and fraScer\UAS.cKa are driven by Scer\GAL4elav.PLu no midline crossing defects are seen. When RhoGAP93BScer\UAS.cHa is driven by Scer\GAL4elav.PLu in a Ptp69Dunspecified;Ptp10Dunspecified background no midline crossing defects are seen. When RhoGAP93BScer\UAS.cHa is driven by Scer\GAL4elav.PLu in a Ptp69D4;Ptp10Dunspecified background no midline crossing defects are seen.

      (Hu, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RhoGAP93BScer\UAS.cHa
      RhoGAP93BUAS.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)