FB2026_03 , released September 17, 2026
Allele: Dmel\Aplip1+tHa
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General Information
Symbol
Dmel\Aplip1+tHa
Species
D. melanogaster
Name
FlyBase ID
FBal0190793
Feature type
allele
Associated gene
Dmel\Aplip1
Associated Insertion(s)
Carried in Construct
P{Aplip1+tHa}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Horiuchi et al., 2005)
wild_type
(Horiuchi et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Horiuchi et al., 2005)
wild_type
(Horiuchi et al., 2005)
Mutagen
in vitro construct
(Horiuchi et al., 2005, Horiuchi et al., 2005)
Progenitor genotype
Carried in construct
P{Aplip1+tHa}
Cytology
Description

Genomic fragment containing full-length Aplip1 coding region plus 1.6kb upstream and 3.4kb downstream.

(Horiuchi et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Aplip1
Encoded product / tool
Aplip1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:1,194,943..1,202,027 [+]
Comment:

approximate boundaries of rescue fragment; reported as containing the Aplip1 coding region plus 1.6kb upstream and 3.4kb downstream genomic sequences.

(Horiuchi et al., 2005, Horiuchi et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Aplip1EK4/+; Khc27/+ larvae show posterior paralysis in 86% of cases; these mutants also show axonal swelling. Expression of the Aplip1+tHa transgene fully rescues the posterior paralysis phenotype of Aplip1EK4/+; Khc27/+ larvae and partially rescues the axonal swelling phenotype.

      (Horiuchi et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Aplip1+tHa
      aplip1gen.rescue
      (Siebert et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)