FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gwlunspecified
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General Information
Symbol
Dmel\gwlunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0190875
Feature type
allele
Associated gene
Dmel\gwl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous or hemizygous gwlunspecified third instar larval brain neuroblasts are mitotic progression defective, with delays in late G2/prophase and the metaphase/anaphase transition. The mitotic index in gwlunspecified third instar larval brain neuroblasts is ~2.5-fold higher than in controls, and the proportion of anaphase/telophase cells is ~10-15% that in wild-type. The fraction of cells in late G2/prophase is elevated, indicating that nuclear envelope breakdown is delayed. In addition, mutant cells in which nuclear envelope breakdown has occurred are subsequently delayed in entering anaphase. Almost all residual anaphase/telophase cells are aberrant, with lagging chromosomes or chromosome bridges. However, the spindle in gwlunspecified mutants is morphologically normal in all mitotic stages.

        (Yu et al., 2004)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        gwlunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (2)