FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lolarev6
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General Information
Symbol
Dmel\lolarev6
Species
D. melanogaster
Name
FlyBase ID
FBal0191061
Feature type
allele
Associated gene
Dmel\lola
Associated Insertion(s)
P{GSV1}GS88A8
Carried in Construct
Also Known As
GS88A8, eyeful
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ferres-Marco et al., 2006)
Progenitor genotype
lolaGS88A8
(Ferres-Marco et al., 2006)
Associated Insertion(s)
P{GSV1}GS88A8
Cytology
Description

The P{GSV1}lolaGS88A8 insertion is still present on the chromosome.

(Ferres-Marco et al., 2006)

Amino acid replacement: W11term.

(Ferres-Marco et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{GSV1}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,533,718..10,533,718 [-]
Nucleotide change:

G10533718A

Amino acid change:

W11term | lola-PA; W11term | lola-PAA; W11term | lola-PB; W11term | lola-PC; W11term | lola-PD; W11term | lola-PE; W11term | lola-PF; W11term | lola-PG; W11term | lola-PH; W11term | lola-PI; W11term | lola-PJ; W11term | lola-PK; W11term | lola-PL; W11term | lola-PM; W11term | lola-PO; W11term | lola-PP; W11term | lola-PQ; W11term | lola-PR; W11term | lola-PT; W11term | lola-PU; W11term | lola-PV; W11term | lola-PW; W11term | lola-PX; W11term | lola-PY; W11term | lola-PZ

Reported amino acid change:

W11term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Ferres-Marco et al., 2006)
transposable_element_insertion_site
2R:10,538,429..10,538,429 [-]
(Ferres-Marco et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying psqGS88A8 and lolarev6 have reduced eye tumour size (compared to flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying psqGS88A8 and lolaGS88A8) but show sporadic secondary growth of eye tissue.

      (Ferres-Marco et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: the P{GSV1}lolaGS88A8 chromosome. Selected as: a mutation that reverts the tumour phenotype caused by overexpression of both psq and lola from the P{GSV1}lolaGS88A8 insertion under the control of Scer\GAL4ey.PH in the presence of DlScer\UAS.cDa.

      (Ferres-Marco et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lolarev6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)