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General Information
Symbol
Dmel\lolarev6
Species
D. melanogaster
Name
FlyBase ID
FBal0191061
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GS88A8, eyeful
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G10533718A

Amino acid change:

W11term | lola-PA; W11term | lola-PAA; W11term | lola-PB; W11term | lola-PC; W11term | lola-PD; W11term | lola-PE; W11term | lola-PF; W11term | lola-PG; W11term | lola-PH; W11term | lola-PI; W11term | lola-PJ; W11term | lola-PK; W11term | lola-PL; W11term | lola-PM; W11term | lola-PO; W11term | lola-PP; W11term | lola-PQ; W11term | lola-PR; W11term | lola-PT; W11term | lola-PU; W11term | lola-PV; W11term | lola-PW; W11term | lola-PX; W11term | lola-PY; W11term | lola-PZ

Reported amino acid change:

W11term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{GSV1}lolaGS88A8 insertion is still present on the chromosome.

Amino acid replacement: W11term.

Insertion components
P{GSV1}GS88A8
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying psqGS88A8 and lolarev6 have reduced eye tumour size (compared to flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying psqGS88A8 and lolaGS88A8) but show sporadic secondary growth of eye tissue.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Induced on: the P{GSV1}lolaGS88A8 chromosome. Selected as: a mutation that reverts the tumour phenotype caused by overexpression of both psq and lola from the P{GSV1}lolaGS88A8 insertion under the control of Scer\GAL4ey.PH in the presence of DlScer\UAS.cDa.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
lolarev6
Name Synonyms
Secondary FlyBase IDs
    References (1)