FB2026_03 , released September 17, 2026
Allele: Dmel\knk::Tsf2TM.UAS
Open Close
General Information
Symbol
Dmel\knk::Tsf2TM.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0191819
Feature type
allele
Associated gene
knk::Tsf2
Associated Insertion(s)
Carried in Construct
P{UAS-knk.TM}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Moussian et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-knk.TM}
Cytology
Description

UAS regulatory sequences drive expression of knk in which the predicted GPI anchor has been replaced with the transmembrane portion of Tsf2 (Tsf2 sequence that could code for the predicted recognition domains required for GPI-modification are not included).

(Moussian et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
knk::Tsf2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of knk::Tsf2TM.Scer\UAS under the control of Scer\GAL4tub suppresses both the knkunspecified lethality and the tracheal and cuticle defects.

      knk::Tsf2TM.Scer\UAS expression, under the control of Scer\GAL4btl.PS in Fas2EB112 or pckG0012 mutant tracheal epithelia is unable to restore their chitin-filament structure and tube size defects.

      Expression of knk::Tsf2TM.Scer\UAS under the control of Scer\GAL4αTub84B.PK suppresses both the knkunspecified lethality and the tracheal and cuticle defects. knk::Tsf2TM.Scer\UAS expression, under the control of Scer\GAL4btl.PS in Fas2EB112 or pckG0012 mutant tracheal epithelia is unable to restore their chitin-filament structure and tube size defects.

      (Moussian et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      knk::Tsf2TM.Scer\UAS
      knk::Tsf2TM.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)