FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Zfrp8M-1-1
Open Close
General Information
Symbol
Dmel\Zfrp8M-1-1
Species
D. melanogaster
Name
FlyBase ID
FBal0193290
Feature type
allele
Associated gene
Dmel\Zfrp8
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Minakhina et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: E296K.

(Minakhina et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,135,012..24,135,012 [+]
Nucleotide change:

G24135012A

Amino acid change:

E296K | Zfrp8-PA; E296K | Zfrp8-PB

Reported amino acid change:

E296K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Minakhina et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      More than 90% of hemizygous and homozygous late third instar larvae produce melanotic masses that are seen as black spots outlining the shape of the lymph glands in pupae. Approximately 5% of homozygotes survive to adulthood.

      The number of circulating hemocytes in mutant third instar larvae is increased about six times compared to wild type.

      Homozygous late third larval instar lymph glands show an increase in the mitotic index compared to controls. The increase in mitotic cells is concentrated in the secondary lymph gland lobes.

      (Minakhina et al., 2007)

      Homozygous and Zfrp8M-1-1/Df(2R)SM183 mutant third instar larvae have melanotic nodules found in the lymph glands. In Zfrp8M-1-1/Df(2R)SM183 third instar larvae, some melanotic nodules are surrounded by lamellocytes and some are surrounded by prohemocytes.

      (Minakhina and Steward, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Zfrp8M-1-1
      (Takada et al., 2025, Minakhina et al., 2007)
      zfrp8M-1-1
      (Minakhina and Steward, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)