FB2026_02 , released June 18, 2026
Allele: Dmel\rho-7pΔ1
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General Information
Symbol
Dmel\rho-7pΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0193462
Feature type
allele
Associated gene
Dmel\rho-7
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    rho-7CB-0229-3
    (McQuibban et al., 2006)
    Cytology
    Description

    Imprecise excision of P{RS3}CB-0229-3 deletes 135 nucleotides, including the transcriptional start site and the first 18 codons of the protein. This deletion also disrupts the mitochondrial targeting sequence.

    (McQuibban et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Approximately 90% of rho-7pΔ1 flies die before pupariation. Death occurs during both embryonic and larval stages, but those that survive to pupariation develop to adults, although approximately 10% of these die during the process of eclosion, and they get stuck while crawling from the pupal case. Surviving flies appear morphologically normal but all die within 3 days. Males are sterile but the females are fertile. The progeny of homozygous females exhibit exactly the same severity of phenotype as their parental generation and are not rescued by wild-type sperm, demonstrating that there is no maternal or paternal rescue of the homozygous zygotic phenotype.

        The testes of homozygous rho-7pΔ1 males do not exhibit gross morphological disruptions, although the seminal vesicle is small and appears empty with no mature sperm.

        rho-7pΔ1 mutant testicles exhibit irregularly-shaped nebenkerns, composed of many individual mitochondria that have coalesced beside the nucleus, but have failed to fuse.

        Surviving adult rho-7pΔ1 mutants are morphologically normal, with the exception ofa wing-position defect, in which the wings of about 60% of individuals hang down on either side of the abdomen. The indirect flight muscles of these mutants exhibit a general disruption of the normal continuous pattern of the phase-dark banding. They exhibit numerous small mitochondria in the space between the myofibrils, as compared to larger mitochondria that completely fill the intramyofibril space in control flies.

        rho-7pΔ1 mutant flies live for only 3 days. These flies also have extreme difficulty walking, and display erratic twitching in their legs and head. Synaptic transmission across the retina is impaired in rho-7pΔ1 flies. Both on- and off-transients are significantly smaller in rho-7pΔ1 flies compared to controls, with the off-transients exhibiting strong time and intensity dependency. The response of photoreceptors in rho-7pΔ1mutants is less than half of those of control photoreceptors, indicating reduced responsiveness to repetitive stimulation.

        After 3 days of continuous light, rho-7pΔ1 mutant photoreceptors degenerate severely, with an almost complete loss of distinct rhabdomeres. These eyes show no detectable degeneration under normal light or dark conditions.

        (McQuibban et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Suppressor of
        Statement
        Reference

        rho-7pΔ1 is a non-suppressor of visible | adult stage phenotype of Pink1UAS.Tag:HA, Scer\GAL4GMR.PF

        (Whitworth et al., 2008)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        rho-7pΔ1 is a suppressor | partially of wing phenotype of Scer\GAL4Bx-MS1096, fogUAS.cRa

        (Ratnaparkhi, 2013)

        rho-7pΔ1 is a suppressor | partially of wing | male limited phenotype of Scer\GAL4Bx-MS1096, fogUAS.cRa

        (Ratnaparkhi, 2013)
        NOT Suppressor of
        Statement
        Reference

        rho-7pΔ1 is a non-suppressor of eye | adult stage phenotype of Pink1UAS.Tag:HA, Scer\GAL4GMR.PF

        (Whitworth et al., 2008)

        rho-7pΔ1 is a non-suppressor of ommatidium | adult stage phenotype of Pink1UAS.Tag:HA, Scer\GAL4GMR.PF

        (Whitworth et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Approximately 43.5% of Scer\GAL4Bx-MS1096>fogScer\UAS.cRa/rho-7pΔ1 males show rescue of the wing phenotype whereas 37% show only a partial rescue, indicating that rho-7 is a suppressor of fog signalling.

        (Ratnaparkhi, 2013)

        rho-7pΔ1 does not suppress the disorganised eye phenotype seen when Pink1Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.

        (Whitworth et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        rho-7pΔ1
        ΔRho-7
        (Ratnaparkhi, 2013)
        Name Synonyms
        rhomboid-7pΔ1
        (McQuibban et al., 2006)
        rhomboid-7ΔP
        (Whitworth et al., 2008)
        Secondary FlyBase IDs
          References (3)