FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRα6DAS2
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General Information
Symbol
Dmel\nAChRα6DAS2
Species
D. melanogaster
Name
FlyBase ID
FBal0193529
Feature type
allele
Associated gene
Dmel\nAChRα6
Associated Insertion(s)
Carried in Construct
Also Known As
nAcRα-30DDAS2, nAChRalpha6DAS2
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Watson et al., 2010, Cook, 2006.12.5)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Watson et al., 2010)

Amino acid replacement: W458term.

(Watson et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:9,797,706..9,797,706 [-]
Nucleotide change:

G9797706A

Reported nucleotide change:

G?A

Amino acid change:

W458term | nAChRalpha6-PA; W458term | nAChRalpha6-PB; W458term | nAChRalpha6-PC; W473term | nAChRalpha6-PD; W487term | nAChRalpha6-PE; W458term | nAChRalpha6-PG; W458term | nAChRalpha6-PH

Reported amino acid change:

W458term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Watson et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant adults are specifically resistant to spinosyns and synthetically-modified spinosyns compared to controls, but are not resistant to other insecticides.

      (Watson et al., 2010)

      nAcRα-30DDAS2 mutants exhibit resistance to the insecticide spinosad.

      (Cook, 2006.12.5)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      nAChRα6DAS2 is an enhancer of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      nAChRalpha6DAS2
      (Bazzi et al., 2023, Lopez-Gonzalez et al., 2019)
      nAChRα6DAS2
      nAcRalpha-30DDAS2
      (Cook, 2006.12.5)
      nAcRα-30DDAS2
      (Walker et al., 2013, Ping and Tsunoda, 2011, Watson et al., 2010)
      rsn3
      (Watson et al., 2010)
      rsn4
      (Watson et al., 2010)
      rsn5
      (Watson et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)