FlyBase Allele Report: Dmel\FER[Δex1]

General Information

Symbol

Dmel\FER^Δex1

Species

D. melanogaster

Name

FlyBase ID

FBal0193666

Feature type

allele

Associated gene

Dmel\FER

Associated Insertion(s)

P{GawB}FER^Δex1

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Murray et al., 2006)

Mutagen

P-element activity

(Murray et al., 2006)

Progenitor genotype

P{GawB}MZ465

(Murray et al., 2006)

Associated Insertion(s)

P{GawB}FER^Δex1

Cytology

Description

Imprecise excision of the P{GawB} element which removes the promoter and first exon of the Fps85D gene. The P{GawB} element insertion is retained.

(Murray et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Murray et al., 2006)

viable

(Murray et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Fps85D^Δex1 embryos complete dorsal closure normally and exhibit normal leading edge morphology.

(Murray et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

FER^Δex1 is an enhancer of lethal | embryonic stage phenotype of Src42A^myri

(Murray et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

FER^Δex1 is an enhancer of embryonic leading edge cell & actomyosin phenotype of Src42A^myri

(Murray et al., 2006)

FER^Δex1 is an enhancer of embryo | dorsal closure stage phenotype of Src42A^myri

(Murray et al., 2006)

FER^Δex1 is an enhancer of embryonic/larval mouth phenotype of Src42A^myri

(Murray et al., 2006)

FER^Δex1 is an enhancer of larval dorsal hair phenotype of Src42A^myri

(Murray et al., 2006)

FER^Δex1 is an enhancer of embryonic/first instar larval cuticle phenotype of Src42A^myri

(Murray et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Src42A^myri; Fps85D^Δex1 double mutant embryos show an enhanced embryonic phenotype compared to Src42A^myri embryos. Src42A^myri; Fps85D^Δex1 leading edge cells show a greater disruption of the actomyosin cable, resulting in a more irregular profile. The embryos show delayed dorsal closure, as 85% are still undergoing closure at late stage 16. Embryonic lethality is increased to 100% (vs 63% in Src42A^myri embryos). 95% of the double mutant embryos show breaks and irregularities in the dorsal hair pattern and a small anterior hole in the mouthparts. The remaining embryos fail to complete dorsal closure and have a large anterior hole.

(Murray et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

FER^Δex1

Fps85D^Δex1

dfer^Δex1

(Murray et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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