FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eys2
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General Information
Symbol
Dmel\eys2
Species
D. melanogaster
Name
FlyBase ID
FBal0193677
Feature type
allele
Associated gene
Dmel\eys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zelhof, 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: G379D.

(Zelhof, 2006)

Nucleotide substitution: G1136A.

(Zelhof, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,339,140..2,339,140 [+]
Nucleotide change:

G2339140A

Reported nucleotide change:

G1136A

Amino acid change:

G390D | eys-PE; G390D | eys-PF

Reported amino acid change:

G379D

Comment:

The difference between the reported and annotated positions of the amino acid change in the mutant results from the use of a downstream translation start in the previous eys annotation and the publication. The annotation was updated in T5.55 to start at an in-frame ATG which is 11aa upstream.

(Zelhof, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Produces near normal levels of eys protein. However, the protein fails to be secreted.

      (Zelhof, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eys2
      spam2
      (Zelhof, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)