FB2026_02 , released June 18, 2026
Allele: Dmel\vgRNAi.UAS
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General Information
Symbol
Dmel\vgRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0194251
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

Scer\GAL4 regulatory sequences drive expression of dsRNA corresponding to the second exon of vg.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of vgdsRNA.Scer\UAS under the control of Scer\GAL4Dll-md23 or Scer\GAL4en-e16E results in a reduction in adult wing size in both an autonomous and nonautonomous manner; greater reductions in size are seen when flies are raised at higher temperatures, at least in the case of Scer\GAL4Dll-md23-mediated expression. The reduction in size of the adult wing is not associated with changes in cell death or cell size during imaginal development.

Clones of cells expressing vgdsRNA.Scer\UAS in the prospective wing blade of the wing imaginal disc frequently (81%) show an atypical morphology: they become narrower where the amount of vg is highest, thus forming a triangular shape pointing towards the prospective wing margin.

Cell clones expressing vgdsRNA.Scer\UAS under the control of Scer\GAL4αTub84B.PL (generated using the MARCM technique) in the prospective wing blade of the wing disc have a significantly longer doubling time (lower rate of proliferation) compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Expression of vgdsRNA.Scer\UAS produces dsRNA which results in dsRNA interference (RNAi) of the vg gene.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
vgRNAi.UAS
vgdsRNA.Scer\UAS
vgdsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)