FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Delta::SerSer-E.Delta-I.UAS
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General Information
Symbol
Dmel\Delta::SerSer-E.Delta-I.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0194257
Feature type
allele
Associated gene
Delta::Ser
Associated Insertion(s)
Carried in Construct
P{UAS-Ser::Delta.L}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Li and Baker, 2004)
Progenitor genotype
Carried in construct
P{UAS-Ser::Delta.L}
Cytology
Description

Amino acid replacement: Y1248S.

(Li and Baker, 2004)

UASt regulatory sequences drive expression of a Ser-Dl fusion protein which comprises the extracellular and transmembrane domains of Ser and the intracellular domain of Dl. Nucleotides encoding Tyr1248 and Arg1249 (at the cytoplasmic face of the transmembrane domain) of the Ser protein are replaced with an XbaI restriction site (which encodes Ser and Arg). The initiating ATG codon of Ser is replaced with a BspH1 restriction site which results in replacing Phe2 with Ile. The endogenous Ser 5'UTR is replaced with a HindIII-NcoI fragment of the Xenopus β-globin gene leader. The 3'UTR of the Dl c1 cDNA terminates 242bp 3' to the predicted stop codon and SV40 polyadenylation sequences are present.

(Li and Baker, 2004)

Amino acid replacement: F2I.

(Li and Baker, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Delta::Ser
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The effects of expressing Dl::SerSer-E.Dl-I.Scer\UAS resemble those of expressing Ser, suggesting that the functional properties of this fusion protein map to the extracellular and transmembrane domains.

      (Li and Baker, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Delta::SerSer-E.Delta-I.UAS
      Delta::SerSer-E.Dl-I.UAS
      Dl::SerSer-E.Dl-I.Scer\UAS
      Dl::SerSer-E.Dl-I.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)