FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lacZMESO.dome.hs
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General Information
Symbol
Ecol\lacZMESO.dome.hs
Species
E. coli
Name
FlyBase ID
FBal0194750
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{dome-lacZ.MESO}
Also Known As
dome-MESO, domeMESO-lacZ
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hombria et al., 2005)
Progenitor genotype
Carried in construct
P{dome-lacZ.MESO}
Cytology
Description

A 2.8kb fragment of dome, containing part of the first exon and most of the first intron, and a minimal heat shock promoter of a lacZ reporter.

(Hombria et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
dome_dome-MESO
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 14
      pharynx
      (Hombria et al., 2005)
      mesoderm of hindgut | anterior
      (Hombria et al., 2005)
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      medullary zone of lymph gland primary lobe
      (Charroux and Royet, 2009)
      Additional Information
      Statement
      Reference

      ScerGAL4Hml.Δ drives expression in all hemocytes at all post embryonic stages; expression is not observed in even late embryos. ScerGAL4Hml.Δ-driven expression is also observed in a group of 50 hemocytes within the larval proventriculus, and in a few cells in the gut epithelium.

      (Charroux and Royet, 2009)
       
      Marker for
      medullary zone of lymph gland primary lobe
      (Charroux and Royet, 2009)
      Reflects expression of
      dome
      (Charroux and Royet, 2009, Hombria et al., 2005)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ecol\lacZMESO.dome.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (11)