FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gbRNAi.UAS
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General Information
Symbol
Dmel\gbRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0195508
Feature type
allele
Associated gene
Dmel\gb
Associated Insertion(s)
Carried in Construct
P{UAS-gb.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Augustin et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Augustin et al., 2007)
Mutagen
in vitro construct
(Augustin et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-gb.RNAi}
Cytology
Description

An inverted repeat of a 767bp fragment of wild-type gb, separated by a w intron, is under the control of UAS sequences.

(Augustin et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
gb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval neuromuscular junction & postsynaptic membrane, with Scer\GAL4Tub.PU

      (Augustin et al., 2007)
      Detailed Description
      Statement
      Reference

      Males expressing gbdsRNA.Scer\UAS under the control of Scer\GAL4αTub84B.PL show a significant amount of homosexual behaviour.

      Males expressing gbdsRNA.Scer\UAS under the control of Scer\GAL4repo show a significant amount of homosexual behaviour, although less than seen when the Scer\GAL4αTub84B.PL driver is used.

      (Grosjean et al., 2008)

      The neuromuscular junctions of larvae expressing gbdsRNA.Scer\UAS under the control of Scer\GAL4tub (thus producing gb RNAi) show a large increase in postsynaptic glutamate receptor number. Consistently, the mean amplitude of spontaneous excitatory junction currents (sEJCs) from the L3 muscle 6 NMJ of these larvae ia larger than that from controls, but Scer\GAL4tub>gbdsRNA.Scer\UAS larvae do not show increase in sEJC frequency compared with wild-type controls.

      (Augustin et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transcription from the P{UAS-gb.RNAi} construct should produce gb dsRNA, resulting in dsRNA interference (RNAi) of the gb gene.

      (Augustin et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gbRNAi.UAS
      gbdsRNA.Scer\UAS
      gbdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)