FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eEFSecKO46
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General Information
Symbol
Dmel\eEFSecKO46
Species
D. melanogaster
Name
FlyBase ID
FBal0197149
Feature type
allele
Associated gene
Dmel\eEFSec
Associated Insertion(s)
Carried in Construct
Also Known As
KO#46
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Hirosawa-Takamori et al., 2004)
I-SceI
(Hirosawa-Takamori et al., 2004)
FLPase
(Hirosawa-Takamori et al., 2004)
I-CreI
(Hirosawa-Takamori et al., 2004)
gene targeting by homologous recombination
(Hirosawa-Takamori et al., 2004)
Progenitor genotype
Cytology
Description

Mutated form of EfSec which has a deletion of less than 1kb, carries two TAA stop codons and has a frameshift.

(Hirosawa-Takamori et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult eEFSecKO46 flies fed on corn meal food do not exhibit any significant reproductive or lifespan changes compared to wild-type flies.

      Adult eEFSecKO46 flies fed a chemically defined diet, which includes Grace's insect medium, low melting point agarose, and p-hydroxybenzoic acid methyl ester, exhibit a 44% reduction in their mean lifespan, compared to that of flies fed corn meal food. In addition, this chemically-controlled diet does not support the development of flies to adult animals. Survivorship of flies on the diet supplemented with or without 100nM sodium selenite is identical.

      (Shchedrina et al., 2011)

      Mutant flies have a normal lifespan and their response to oxidative stress is indistinguishable from wild type.

      (Hirosawa-Takamori et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EfSecKO46
      KO#46
      (Shchedrina et al., 2011, Hirosawa-Takamori et al., 2004)
      eEFSecKO46
      Name Synonyms
      Secondary FlyBase IDs
        References (2)