FB2026_03 , released September 17, 2026
Allele: Dmel\mfrZ2942
Open Close
General Information
Symbol
Dmel\mfrZ2942
Species
D. melanogaster
Name
FlyBase ID
FBal0197733
Feature type
allele
Associated gene
Dmel\mfr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith, 2007)
Progenitor genotype
Cytology
Description

The mutation in this allele disrupts the splice donor in an intron.

(Smith, 2007)

Nucleotide substitution: G8899358A.

(Smith, 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,906,258..8,906,258 [-]
Nucleotide change:

G8906258A

Reported nucleotide change:

G8899358A

Reported amino acid change:

Y1627term

Comment:

The mutation in this allele disrupts the splice donor in an intron. The mutations were reported relative to the longest mfr protein isoform, which uses an upstream ATG start relative to the annotated version in release 5.54.

(Smith, 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In crosses of mfrZ2942/Df(3L)h-i22 males to wild-type females, 100% of eggs are inseminated in comparison to controls. The sperm undergo nuclear condensation and reach the pronuclear apposition stage, but fail to progress beyond this stage.

      Egg patterning is not affected in mfrZ2942/Df(3L)h-i22 females.

      (Smith, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a male sterile mutation from the Zuker collection.

      (Smith, 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mfrZ2942
      (Smith, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)