FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spoZ303
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General Information
Symbol
Dmel\spoZ303
Species
D. melanogaster
Name
FlyBase ID
FBal0197743
Feature type
allele
Associated gene
Dmel\spo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ono et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: G481E.

(Ono et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:5,590,777..5,590,777 [-]
Nucleotide change:

G5590777A

Amino acid change:

G481E | spo-PA; G481E | spo-PC

Reported amino acid change:

G481E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ono et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      spoZ339/spoZ303 embryos rarely hatch. When an artificial pulse of 20E is delivered to these embryos midway through embryogenesis, approximately 30% survive to hatch and 20% survive to adulthood. Rescued spoZ339/spoZ303 females produce no progeny due to arrest of egg development at stage 8 of oogenesis, while rescued males are fertile.

      An artificial pulse of E allows 25% of spoZ339/spoZ303 embryos to hatch and 12% to become adults. A pulse of ketotriol allows 13% to hatch but only 1% survive to become adults. In contrast, pulses of ketodiol and 7dC do not rescue the lethality of spoZ339/spoZ303 embryos at all.

      (Ono et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DmspoZ303
      (Ono et al., 2006)
      spoZ303
      Name Synonyms
      Secondary FlyBase IDs
        References (1)