FB2026_02 , released June 18, 2026
Allele: Dmel\Fmr1I307N
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General Information
Symbol
Dmel\Fmr1I307N
Species
D. melanogaster
Name
FlyBase ID
FBal0197927
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
Carried in Construct
P{Fmr1I307N}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Banerjee et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Banerjee et al., 2007)
Mutagen
in vitro construct
(Banerjee et al., 2007)
Progenitor genotype
Fmr1+t14
(Banerjee et al., 2007)
Carried in construct
P{Fmr1I307N}
Cytology
Description

Amino acid replacement: I307N.

(Banerjee et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Fmr1
Encoded product / tool
Fmr1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:10,105,109..10,105,109 [-]
Nucleotide change:

T10105109A

Amino acid change:

I307N | Fmr1-PA; I307N | Fmr1-PB; I307N | Fmr1-PC; I307N | Fmr1-PD; I269N | Fmr1-PE; I269N | Fmr1-PF; I355N | Fmr1-PG; I355N | Fmr1-PH; I269N | Fmr1-PI; I307N | Fmr1-PJ; I307N | Fmr1-PK

Reported amino acid change:

I307N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Banerjee et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      neuron & beta-lobe, with Fmr13

      (Banerjee et al., 2007)
      Detailed Description
      Statement
      Reference

      Flies carrying one copy of Fmr1I307N in a homozygous Fmr13 background show no significant increase in the number of type I boutons at the larval neuromuscular junction compared to wild type (muscles 6/7, 12 and 4 from segment A3 have been studied).

      Flies carrying Fmr1I307N in a homozygous Fmr13 background show an increased frequency of midline crossing of mushroom body β-lobe neurons compared to controls.

      Animals carrying Fmr1I307N in a homozygous Fmr13 background show a significant increase in the percentage of flies that are arrhythmic for locomotor activity under constant darkness conditions compared to controls.

      Animals carrying Fmr1I307N in a homozygous Fmr13 background show a reduced courtship index towards virgin females than that seen in wild-type males.

      (Banerjee et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fmr1I307N
      (Bhogal et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)