FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\αTub67Ckav-rX21
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General Information
Symbol
Dmel\αTub67Ckav-rX21
Species
D. melanogaster
Name
FlyBase ID
FBal0198519
Feature type
allele
Associated gene
Dmel\αTub67C
Associated Insertion(s)
Carried in Construct
Also Known As
kavarnull, kavarrX21
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Venkei and Szabad, 2005)
Mutagen
X ray
(Venkei et al., 2006, Venkei and Szabad, 2005)
Progenitor genotype
αTub67Ckav-21g
(Gaspar and Szabad, 2009)
Cytology
Description

Deletion of 4bp near the 5' end of the αTub67C ORF (C56TGC) leads to frameshift from the 19th codon. The predicted product is only 34 amino acids long.

(Venkei and Szabad, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:9,681,956..9,681,959 [+]
Comment:

Deletion of four base pairs (CTGC) leads to a frameshift from the 19th codon.

(Venkei and Szabad, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos of αTub67Ckav-rX21 hemizygous mothers display an abnormal cortical microtubule network. A network of only short microtubules without directionality is observed.

      (Fahmy et al., 2014)

      Ooplasmic streaming occurs in the oocytes of αTub67Ckav-rX21/Df(3L)55 females, although the average streaming velocity is 317+/-8 nm/second compared to 348+/-5 nm/second in control females. The average velocity of lipid droplets in the mutant early stage 12 egg chambers is significantly reduced compared to controls, while the average dwell time and average run length are not significantly different from wild type.

      (Gaspar and Szabad, 2009)

      Early stage 12 egg primordia derived from αTub67Ckav-rX21/αTub67Ckav-18c females show no sign of the fast, linear motion of the non-streaming lipid droplet subpopulation that is seen in control egg primordia.

      (Gáspár and Szabad, 2009)

      Microtubule formation following initiation is slower in extracts from αTub67Ckav-rX21/Df(3L)55 embryos than in equivalent extracts from wild-type embryos.

      (Venkei et al., 2006)

      Although eggs laid by αTub67Ckav-rX21/+ females are fertilized, embryogenesis does not begin. The centrosome introduced by the sperm is duplicated and daughter centrosomes form, but these daughter centrosomes fail to move apart along the nuclear envelope and no spindle can be seen between them. Instead they remain closely associated with a tassel of microtubules with over-condensed chromosomes inside - indicative of a collapsed spindle

      (Venkei and Szabad, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced in a screen for reversion of dominant female sterile phenotype of αTub67Ckav-21g as described in FBrf0051088.

      (Venkei and Szabad, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Kavarnull
      (Venkei and Szabad, 2005)
      KavarrX21
      (Venkei and Szabad, 2005)
      kavar0
      (Venkei et al., 2006)
      kavarnull
      (Gáspár and Szabad, 2009, Gaspar and Szabad, 2009)
      kavarrX21
      (Gaspar and Szabad, 2009)
      αTub67Ckav-rX21
      Name Synonyms
      kavarnull
      (Fahmy et al., 2014)
      kavarrX21
      (Fahmy et al., 2014)
      Secondary FlyBase IDs
        References (5)