FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\woc964
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General Information
Symbol
Dmel\woc964
Species
D. melanogaster
Name
FlyBase ID
FBal0212643
Feature type
allele
Associated gene
Dmel\woc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Raffa et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: D1464Y.

(Raffa et al., 2005)

Nucleotide substitution: G?T.

(Raffa et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,258,297..27,258,297 [-]
Nucleotide change:

G27258297T

Reported nucleotide change:

G?T

Amino acid change:

D1464Y | woc-PA; D1479Y | woc-PB; D488Y | woc-PC; D1463Y | woc-PD; D1478Y | woc-PE

Reported amino acid change:

D1464Y

(Raffa et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae are able to pupariate, but die prior to eclosion.

      The brains of homozygous, woc964/Df(3R)mbtP and woc964/wocrgl larvae show a high frequency of telomere-telomere attachments compared to controls. Single telomere attachments in which a single telomere fuses with its sister telomere, or in which a single telomere fuses with another single nonsister telomere are both seen. Double telomere attachments, where a pair of sister telomeres join with another pair are seen; both monocentric ring chromosomes and linear dicentric chromosomes are seen. In addition, multiple double telomere attachments, resulting in multicentric rings or linear chromosomes, are also seen. The average number of telomere-telomere attachments per cell is 1.82 in homozygotes, 1.67 in woc964/wocrgl animals and 1.58 in woc964/Df(3R)mbtP animals.

      Polytene chromosomes derived from homozygous larvae are normal in size.

      (Raffa et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: A mutation that shows frequent telomere-telomere attachments in cells of the larval brain.

      (Raffa et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      woc964
      (Raffa et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)