FlyBase Allele Report: Dimm\osk[imm]

General Information

Symbol

Dimm\osk^imm

Species

D. immigrans

Name

FlyBase ID

FBal0212743

Feature type

allele

Associated gene

Dimm\osk

Associated Insertion(s)

Carried in Construct

P{osk^imm}

Transgenic product class

genomic_DNA

(Jones and Macdonald, 2007)

wild_type

(Jones and Macdonald, 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Jones and Macdonald, 2007)

wild_type

(Jones and Macdonald, 2007)

Mutagen

in vitro construct

(Jones and Macdonald, 2007)

Progenitor genotype

Carried in construct

P{osk^imm}

Cytology

Description

Corresponds to a 8.7kb NotI-Asp718 genomic fragment that includes 5kb upstream of the start codon and 1kb downstream of the polyadenylation site.

(Jones and Macdonald, 2007)

Allele components

Component

Use(s)

Encoded product / tool

Dimm\osk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

nuclear body & pole cell

(Jones and Macdonald, 2007)

Detailed Description

Statement

Reference

Expression of Dimm\osk^imm in wild-type D. melanogaster embryos results in a partial transformation of pole cell nuclear bodies towards the morphology observed in D. immigrans embryos.

(Jones and Macdonald, 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Dimm\osk^imm is a suppressor | partially of primordial germ cell phenotype of osk¹/Df(3R)p-XT103

(Jones and Macdonald, 2007)

Dimm\osk^imm is a suppressor | partially of embryo phenotype of osk¹/Df(3R)p-XT103

(Jones and Macdonald, 2007)

Other

Statement

Reference

Dimm\osk^imm, osk¹ has P granule phenotype

(Jones and Macdonald, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Dimm\osk^imm in embryos from osk¹/Df(3R)p-XT103 mothers rescues the body patterning and pole cell formation defects of these mutant embryos; fewer pole cells form than in wild-type embryos, but they are functional. The progression of polar granule development in Dimm\osk^imm; osk¹/Df(3R)p-XT103 embryos is like that seen in D. melanogaster until the cellular blastoderm stage, when the smaller granules accumulate in one area of the cell, so that by gastrulation each pole cell contains a single large aggregate of granule material, like that seen in D. immigrans embryos.

(Jones and Macdonald, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dimm\osk^imm

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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