FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Apc219-3
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General Information
Symbol
Dmel\Apc219-3
Species
D. melanogaster
Name
FlyBase ID
FBal0213106
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
P{?EP}Apc219-3
Carried in Construct
Also Known As
Apc219.3
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Takacs et al., 2008)
Mutagen
Delta2-3 transposase
(Takacs et al., 2008)
Progenitor genotype
P{EP}Apc2G5028
(Takacs et al., 2008)
Associated Insertion(s)
P{?EP}Apc219-3
Cytology
Description

Imprecise excision of the P{EP}Apc2G5028 insertion, resulting in a 2441bp deletion (nucleotides +58 to +2499 relative to the Apc2 transcription start site). 250bp of the P{EP}Apc2G5028 insertion remain at the deletion site.

(Takacs et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:24,164,026..24,166,467 [+]
Comment:

2442 bp deletion resulting from the imprecise excision of the @P{EP}Apc2[G5028]. 250 bp of the insertion remain at the deletion site.

(Takacs et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cells in Apc219-3 mutant wing disc clones in third instar larvae do not display any evident morphological defects compared to neighboring cells.

      (Wang et al., 2016)

      Severe hypomorph.

      (Takacs et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Apc219-3 ApcQ8 double mutant clone cells generated in the medullar region of third instar larval brains segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons do not extend to the medullar neuropil, forming knots in the center of the clones rather than the normal finely fasciculated projections seen in wild type.

      Apc219-3 ApcQ8 AxnS044230 triple mutant clone cells generated in the medullar region of third instar larval brains sometimes segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons extend correctly to the medullar neuropil.

      (Roberts et al., 2012)

      ApcQ8 Apc25-3/ApcQ8 Apc219-3 double mutants show a wing to notum transformation.

      (Takacs et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      APC219-3
      (Roberts et al., 2012)
      APC219-33
      (Roberts et al., 2012)
      Apc219-3
      (Tian et al., 2016, Takacs et al., 2008, Takacs et al., 2008)
      Apc219.3
      (Wu et al., 2025, Tacchelly-Benites et al., 2018, Wang et al., 2016, Wang et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)