FB2026_03 , released September 17, 2026
Allele: Dmel\btl::Egfrλ.Y1271F.UAS
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General Information
Symbol
Dmel\btl::Egfrλ.Y1271F.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0213150
Feature type
allele
Associated gene
btl::Egfr
Associated Insertion(s)
Carried in Construct
P{UAS-λ-Egfr.Y1271F}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Bianco et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-λ-Egfr.Y1271F}
Cytology
Description

UAS sequences regulate expression of a mutated form of 'λ-Egfr' (a Y1271F amino acid replacement has been introduced into the Egfr intracellular domain). FlyBase curator comment: '.lgr;-Egfr' consists of the dimerization domain of the bacteriophage .lgr; cI repressor (included to induce constitutive dimerization of the encoded protein), transmembrane sequence (from btl) and the intracellular domain of Egfr.

(Bianco et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
btl::Egfr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of btl::EgfrY1271F.Scer\UAS.T:λ\cI-DD under the control of Scer\GAL4slbo.2.6 impairs border cell migration.

      (Bianco et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      btl::EgfrY1271F.Scer\UAS.T:λ\cI-DD
      btl::Egfrλ.Y1271F.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)