FlyBase Allele Report: Dmel\cnk[GD11960]

General Information

Symbol

Dmel\cnk^GD11960

Species

D. melanogaster

Name

FlyBase ID

FBal0214904

Feature type

allele

Associated gene

Dmel\cnk

Associated Insertion(s)

Carried in Construct

P{GD11960}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dietzl et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dietzl et al., 2007)

Mutagen

in vitro construct

(Dietzl et al., 2007)

Progenitor genotype

Carried in construct

P{GD11960}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dietzl et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11960

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

Phenotype Manifest In

wing, with Scer\GAL4^en-e16E

(Hahn et al., 2013)

wing vein, with Scer\GAL4^en-e16E

(Hahn et al., 2013)

Detailed Description

Statement

Reference

cnk knockdown in the posterior compartment of the imaginal wing disc, using Scer\GAL4^en-e16E in combination with cnk^GD11960, results in loss of wing vein tissue.

(Hahn et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, cnk^GD11960 has wing phenotype, enhanceable by Scer\GAL4^en-e16E/step^RNAi.UAS

(Hahn et al., 2013)

Scer\GAL4^en-e16E, cnk^GD11960 has wing vein phenotype, enhanceable by Scer\GAL4^en-e16E/step^RNAi.UAS

(Hahn et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, cnk^GD11960 has wing phenotype, suppressible by Scer\GAL4^en-e16E/step^UAS.FL

(Hahn et al., 2013)

Scer\GAL4^en-e16E, cnk^GD11960 has wing vein phenotype, suppressible by Scer\GAL4^en-e16E/step^UAS.FL

(Hahn et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction of wing vein tissue seen upon expression of cnk^GD11960 in the posterior compartment of the imaginal wing disc under the control of Scer\GAL4^en-e16E can be further increased by co-expression of step^{dsRNA.Scer\UAS}. In contrast, expression of step^Scer\UAS.FL in the posterior compartment of the imaginal wing disc, under the control of Scer\GAL4^en-e16E, suppresses the wing vein differentiation defects found upon down-regulation of cnk by expression of cnk^GD11960.

(Hahn et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cnk^GD11960

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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