FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rab40Q75L.UASp.YFP
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General Information
Symbol
Dmel\Rab40Q75L.UASp.YFP
Species
D. melanogaster
Name
FlyBase ID
FBal0215448
Feature type
allele
Associated gene
Dmel\Rab40
Associated Insertion(s)
Carried in Construct
P{UASp-YFP.Rab40.Q75L}
Key Links
Transgenic product class
missense_variant
(Zhang et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Zhang et al., 2007)
Mutagen
in vitro construct
(Zhang et al., 2007, Zhang et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-YFP.Rab40.Q75L}
Cytology
Description

Amino acid replacement: Q75L.

(Zhang et al., 2007)

UASp regulatory sequences drive expression of a predicted constitutively active form of Rab40 that is tagged at the N-terminal end with YFP.

(Zhang et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Rab40
Tagged with
YFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early third instar larvae expressing Rab40Q75L.UASp.YFP under the control of Scer\GAL4Cg.PA display larger lipid droplets in the fat body; early third instar larvae expressing Rab40Q75L.UASp.YFP under the control of Scer\GAL4ppl.PP display ectopic lipid droplets in the salivary glands.

      The expression of Rab40Q75L.UASp.YFP under the control of Scer\GAL4GMR.PFa results in more and larger lipid droplets in retina glial and photoreceptor cells of 1-day old adults.

      (Duan et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Rab40Q75L.UASp.YFP, Scer\GAL4CCAP.PP is a suppressor | partially of wing phenotype of OsbpUAS.cMa, Scer\GAL4CCAP.PP

      (Ma et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Rab40Q75L.Scer\UAS.P\T.T:Avic\GFP-YFP weakly suppresses the uninflated wing phenotype of Scer\GAL4Ccap.PP, OsbpScer\UAS.cMa flies.

      (Ma et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab40Q75L.Scer\UAS.P\T.T:Avic\GFP-YFP
      Rab40Q75L.UASp.YFP
      Name Synonyms
      Secondary FlyBase IDs
        References (8)