FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hppyEP-704
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General Information
Symbol
Dmel\hppyEP-704
Species
D. melanogaster
Name
FlyBase ID
FBal0216196
Feature type
allele
Associated gene
Dmel\hppy
Associated Insertion(s)
P{GSV1}hppyEP-704
Carried in Construct
Also Known As
EP-704
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Resnik-Docampo and de Celis, 2011)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV1}hppyEP-704
    Cytology
    Description

    Insertion into the 5' UTR of hppy.

    (Resnik-Docampo and de Celis, 2011)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV1}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Wing size is reduced when hppyEP-704 is expressed using Scer\GAL4nub-AC-62. In general, the pattern of veins and sensory organs remains normal.

        Co-expression of hppyGD12129 suppresses the small wing phenotype of hppyEP-704, Scer\GAL4nub-AC-62 flies.

        hppyEP-704 homozygotes are viable and exhibit smaller than wild type wings (a reduction of 12%) owing to a weak reduction in cell size. There is a developmental delay of ~2 days during larval stages.

        The small wing phenotype of hppyEP-704flies is significantly rescued when larvae are raised in medium with a high level of protein in relation to sugars, but is made much worse when larvae are starved for proteins.

        (Resnik-Docampo and de Celis, 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Selected as: a P{GSV1} insertion line that when expressed using Scer\GAL4dpp.3KK results in a mutant phenotype in the wing.

        (Molnar et al., 2006)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        EP-704
        (Resnik-Docampo and de Celis, 2011)
        EP-704EP-704
        hppyEP-704
        Name Synonyms
        Secondary FlyBase IDs
          References (2)