FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lup-4HA10
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General Information
Symbol
Dmel\lup-4HA10
Species
D. melanogaster
Name
FlyBase ID
FBal0216853
Feature type
allele
Associated gene
lup-4
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ceprani et al., 2008)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant spermatocytes show an extreme reduction of the kl-3 Y-loop and also show a slight reduction of the kl-5 and kl-1 Y-loops compared to wild type. They show a failure of meiosis, leading to transformation of meiocytes into diploid pseudo-spermatids that initiate but fail to complete differentiation, resulting in cells which have prominent sperm tails which eventually degenerate.

      lup-4HA10/lup-4HA30 males have defects in the kl-3 Y-loop and have immotile sperm.

      (Ceprani et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lup-4HA10
      ms(2)HA10
      (Ceprani et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)