FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aust1
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General Information
Symbol
Dmel\aust1
Species
D. melanogaster
Name
FlyBase ID
FBal0216924
Feature type
allele
Associated gene
Dmel\aust
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Mutation in a splice donor site.

    (Gao et al., 2008)

    Nucleotide substitution: G?A.

    (Gao et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:9,250,752..9,250,752 [-]
    Nucleotide change:

    G9250752A

    Reported nucleotide change:

    G?A

    Comment:

    G to A mutation in the splice donor site.

    (Gao et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous and aust1/Df(2L)30A-C males show defects in meiotic chromosome segregation and cytokinesis.

        aust1/Df(2L)30A-C onion stage spermatids have a single large Nebenkern surrounded by 2, 3, or 4 nuclei of varying size, with more than 75% of cells having four nuclei of irregular size and a single Nebenkern.

        aust1/Df(2L)30A-C meiotic cysts in the testis show an absence of both the central spindle and of furrow ingression during telophase.

        aust1/Df(2L)30A-C males show a number of defects in meiosis I. The number of chromosomal masses during prometaphase I appears to vary between cells, due to separation of sister chromatids. Chromosomes often fail to align correctly on the metaphase plate. Chromosomes often segregate inappropriately during anaphase I.

        aust1/Df(2L)30A-C spermatocytes have normal meiotic spindle morphology in metaphase and early anaphase. The spindles elongate during anaphase, but no central spindle is formed; centrosome nucleated microtubules do reach the cell equator during anaphase (as occurs in wild-type cells), but no microtubule bundling or interdigitation is seen, either at the cell cortex or internally in the mutant cells, and instead the centrosome nucleated microtubules continue to grow from opposite poles toward and past the center of the cell.

        (Gao et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Separable from: a second male sterile mutation on the same chromosome, since two non-overlapping deficiencies result in male sterility in combination with the "aust1" chromosome.

        (Gao et al., 2008)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        aust1
        (Gao et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)