FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PxtEY03052
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General Information
Symbol
Dmel\PxtEY03052
Species
D. melanogaster
Name
FlyBase ID
FBal0217117
Feature type
allele
Associated gene
Dmel\Pxt
Associated Insertion(s)
P{EPgy2}PxtEY03052
Carried in Construct
Also Known As
pxtEY
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Tootle and Spradling, 2008)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}PxtEY03052
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PxtEY03052/PxtEY03052 nurse cells have disperse nucleoli during oogenesis stages 8 and 9, and greatly enlarged and fragmented nucleoli lacking interconnected tubules at stage 10. PxtEY03052/+ heterozygotes display an enlarged and fragmented nucleolus and only a mild decrease in the occurrence of interconnected tubules. The severity of the phenotype in both homozygotes and heterozygotes is greater at oogenesis stage 10B compared to 10A, and in anterior nurse cells.

      (Groen et al., 2015)

      The fertility of homozygous pxtEY03052 females drops with age more rapidly than normal.

      Some pxtEY03052 mutant follicles show defects in nurse cell dumping.

      In both homozygotes and trans-heterozygotes of pxtf01000 and pxt[EY03052], more than 50% of stage 9-10 border cell clusters do not complete migration completely.

      (Tootle and Spradling, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element is accompanied by reversion of the mutant phenotype.

      (Tootle and Spradling, 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PxtEY03052
      pxtEY03052
      (Thomalla et al., 2025, Giedt et al., 2023, Groen et al., 2015, Tootle and Spradling, 2008)
      pxtEY
      (Talbot et al., 2023, Groen et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)