FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rols5a
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General Information
Symbol
Dmel\rols5a
Species
D. melanogaster
Name
FlyBase ID
FBal0217432
Feature type
allele
Associated gene
Dmel\rols
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Pütz et al., 2005)
Progenitor genotype
rolsEP3330
(Pütz et al., 2005)
Cytology
Description

Imprecise excision of P{EP}EP3330 has deleted from -64 to -1632 upstream of the first exon specific to rols isoform 6 (3rd exon of rols). This includes most of the putative rols6 regulatory region.

(Pütz et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Initial determination, budding and elongation of Malpighian tubules during stage 13-14 is normal in rols5a homozygous embryos. However rearrangement of tubule cells to produce elongated, 2 cell wide tubules is delayed (from stage 15 to stage 16-17) and partially disrupted. Tubule migration is defective from stage 15. The anterior tubules follow an erratic path through the body cavity, sometimes doubling back to form loops, and never form the wild-type kink in A2/3. Stellate cell (excretory star cell) integration into the Malpighian tubules appears normal in these embryos.

      Unlike most other rols alleles, rols5a mutants do not exhibit fusion of somatic or visceral muscles.

      (Pütz et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EP(3)3330*5a
      (Pütz et al., 2005)
      rols5a
      Name Synonyms
      Secondary FlyBase IDs
        References (1)