FlyBase Allele Report: Dmel\Mical[G56]

General Information

Symbol

Dmel\Mical^G56

Species

D. melanogaster

Name

FlyBase ID

FBal0217511

Feature type

allele

Associated gene

Dmel\Mical

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Beuchle et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q906term.

(Beuchle et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:10,016,745..10,016,745 [-]

Nucleotide change:

C10016745T

Amino acid change:

Reported amino acid change:

Q906term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Beuchle et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight (with Mical^I666)

(Beuchle et al., 2007)

abnormal neuroanatomy

(Beuchle et al., 2007)

abnormal neuroanatomy (with Mical^I666)

(Hung et al., 2013, Beuchle et al., 2007)

visible (with Df(3R)swp2^MICAL)

(Hung et al., 2010)

Phenotype Manifest In

bouton (with Mical^I666)

(Beuchle et al., 2007)

embryonic/larval neuromuscular junction

(Beuchle et al., 2007)

embryonic/larval neuromuscular junction (with Mical^I666)

(Beuchle et al., 2007)

filamentous actin | third instar larval stage (with Mical^I666)

(Hung et al., 2013)

larval somatic muscle cell (with Mical^I666)

(Beuchle et al., 2007)

larval somatic muscle cell | third instar larval stage (with Mical^I666)

(Hung et al., 2013)

macrochaeta (with Df(3R)swp2^MICAL)

(Hung et al., 2010)

sarcomere (with Mical^I666)

(Beuchle et al., 2007)

synapse (with Mical^I666)

(Hung et al., 2013)

Detailed Description

Statement

Reference

Mical^G56/Mical^I666 larval muscles exhibit abnormal actin accumulations.

Mical^G56/Mical^I666 animals have synaptogenic defects, with a decreased length of synaptic innervation.

(Hung et al., 2013)

Surviving Mical^G56/Df(3R)swp2^MICAL adults usually have defects in bristle morphology.

(Hung et al., 2010)

Mical^G56/Mical^I666 adults are strongly flight defective.

Neuromuscular junctions of Mical^G56/Mical^I666 larvae appear structurally more compressed than controls and synaptic boutons aggregate as clusters in the mutants. The sarcomeric patterning normally seen in the somatic muscles is almost completely lost, and clumped boutons are embedded in disordered myosin filaments.

(Beuchle et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

607155

w^*; P{Mhc.CD8-GFP-Sh}3 Mical^G56/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

G56

(Hung et al., 2010)

Mical^G56

(Hung et al., 2013, Kirilly et al., 2009)

mical^G56

(Beuchle et al., 2007)

milch^G56

(Beuchle et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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