FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaEttd6
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General Information
Symbol
Dmel\ninaEttd6
Species
D. melanogaster
Name
FlyBase ID
FBal0217773
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Meyer et al., 2008)
Progenitor genotype
Cytology
Description

A missense mutation in ninaE leads to a proline to serine substitution. This proline is part of a highly conserved sequence motif (RYVPEG) present in the second extracellular loop of almost all invertebrate rhodopsins.

(Meyer et al., 2008)

Amino acid replacement: P193S.

(Meyer et al., 2008)

Nucleotide substitution: C577T.

(Meyer et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,887,216..19,887,216 [-]
Nucleotide change:

C19887216T

Reported nucleotide change:

C577T

Amino acid change:

P193S | ninaE-PA

Reported amino acid change:

P193S

(Meyer et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The light-triggered translocation of trplninaE.T:Avic\GFP-EGFP is abolished in ninaEttd6 flies.

      (Meyer et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ninaE17

      (Meyer et al., 2008)
      Comments

      ninaEttd6 in trans with ninaE17 displays complete inhibition of trplninaE.T:Avic\GFP-EGFP internalisation in the light.

      (Meyer et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ninaEttd6
      ttd6
      (Meyer et al., 2008)
      Name Synonyms
      TRPL translocation defect 6
      (Meyer et al., 2008)
      Secondary FlyBase IDs
        References (1)