FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\oskUASp.cZa
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General Information
Symbol
Dmel\oskUASp.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS and P\T construct of Zimyanin
FlyBase ID
FBal0217947
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
P{UASp-osk.Z}
Key Links
Transgenic product class
genomic_DNA
(Zimyanin et al., 2007)
wild_type
(Zimyanin et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Zimyanin et al., 2007)
wild_type
(Zimyanin et al., 2007)
Mutagen
in vitro construct
(Zimyanin et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-osk.Z}
Cytology
Description

UASp regulatory sequences drive expression of the osk gene (a BamH1 and Hinc2 genomic DNA fragment).

(Zimyanin et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
osk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos laid by oskScer\UAS.P\T.cZa; Scer\GAL4mat.αTub67C.T:Hsim\VP16 females have an extreme bicaudal phenotype: foregut and hindgut are enlarged and protrude from the ends of the embryo; the telson is duplicated in the anterior and most other cuticular structures (including most or all denticles) are lost.

      (Zimyanin et al., 2007)

      Although oskScer\UAS.P\T.cZa; Scer\GAL4mat.αTub67C.T:Hsim\VP16 females produce some bicaudal embryos, the vast majority show a more extreme phenotype in which the gut and terminal structures are expanded at the expense of the cuticle.

      In stage 9 oskScer\UAS.P\T.cZa; Scer\GAL4mat.αTub67C.T:Hsim\VP16 oocytes, the overall morphology of the the microtubule cytoskeleton is normal, but there are defects in microtubule polarity - in particular an accumulation of microtubule plus ends in the middle of the oocyte.

      (Zimyanin et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      oskScer\UAS.P\T.cZa
      oskUASp.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS and P\T construct of Zimyanin
      Secondary FlyBase IDs
        References (5)