FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmmm\MEK1ΔN3.S218E.S222D.hs
Open Close
General Information
Symbol
Mmmm\MEK1ΔN3.S218E.S222D.hs
Species
m. unknown
Name
FlyBase ID
FBal0219584
Feature type
allele
Associated gene
Mmmm\MEK1
Associated Insertion(s)
Carried in Construct
P{Mmmm\MEK1.ΔN3.S218E.S222D.hs}
Transgenic product class
missense_variant
(Iijima-Ando et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Iijima-Ando et al., 2005)
Mutagen
in vitro construct
(Iijima-Ando et al., 2005)
Progenitor genotype
Carried in construct
P{Mmmm\MEK1.ΔN3.S218E.S222D.hs}
Cytology
Description

A constitutively active form of Mmmm\MEK1, with two amino acid replacements and a deletion of the N3 domain is cloned under the control of a heat-shock promoter.

(Iijima-Ando et al., 2005)

Amino acid replacement: S218E.

(Iijima-Ando et al., 2005)

Amino acid replacement: S222D.

(Iijima-Ando et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Mmmm\MEK1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Addition of Mmmm\MEK1ΔN3.S218E.S222D.hs does not affect survival rate of flies at 18[o]C or 22[o]C.

      (Iijima-Ando et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Heat-shock (35[o]C for 30 minutes each day) of Mmmm\MEK1ΔN3.S218E.S222D.hs increases the survival rate of flies expressing Hsap\HDQ48.ex1p.Scer\UAS in the nervous system under the control of Scer\GAL4elav-C155 at 18[o]C and 22[o]C (~10% at 22[o]C and ~5% at 18[o]C). The increase in survival rate with Mmmm\MEK1ΔN3.S218E.S222D.hs is larger at 22[o]C than at 18[o]C, suggesting that this effect depends upon the level of Mmmm\MEK1ΔN3.S218E.S222D.hs expression.

      (Iijima-Ando et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmmm\MEK1ΔN3.S218E.S222D.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)