Heterozygous Pcl^GE15295 mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with either Gram-negative (Ecc-15) or Gram-positive (M. luteus or S. aureus) bacteria. The number of hemocytes in Pcl^GE15295/+ mutant flies is similar to wild type but these hemocytes are defective in the uptake of B. bassiana fungal spores. Defects are also seen in the phagocytic uptake of E. coli but not S. aureus. An increased number of plasmatocytes and a reduced number of crystal cells are seen in heterozygous Pcl^GE15295 third instar larvae. Less melanisation occurs following injury compared to wild type.