FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\par-170D3
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General Information
Symbol
Dmel\par-170D3
Species
D. melanogaster
Name
FlyBase ID
FBal0220461
Feature type
allele
Associated gene
Dmel\par-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: T?A.

    (McDonald et al., 2008)

    Amino acid replacement: Y415term.

    (McDonald et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:19,471,332..19,471,332 [+]
    Nucleotide change:

    T19471332A

    Reported nucleotide change:

    T?A

    Amino acid change:

    Y415term | par-1-PA; Y538term | par-1-PH; Y415term | par-1-PL; Y643term | par-1-PP; Y643term | par-1-PR; Y415term | par-1-PS; Y643term | par-1-PT; Y415term | par-1-PV; Y415term | par-1-PW; Y415term | par-1-PX

    Reported amino acid change:

    Y415term

    (McDonald et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The severity of the border follicle cell migration defects seen in females expressing par-1dsRNA.Scer\UAS.cMDa under the control of Scer\GAL4c306 are increased if the flies are also heterozygous for par-170D3.

        Border follicle cell migration is disrupted in par-1k06323/par-170D3 females.

        par-1k06323/par-170D3 border follicle cells extend protrusions as occurs in wild-type border cells, but in contrast to wild-type cells, where the protrusions are extended mainly in the forward direction (in the direction of migration), in the mutant cells forward protrusions are decreased at the expense of backward and lateral protrusions.

        (McDonald et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        70D3
        (McDonald et al., 2008)
        par-170D3
        Name Synonyms
        Secondary FlyBase IDs
          References (1)