FlyBase Allele Report: Dmel\TpnC41C[JF02379]

General Information

Symbol

Dmel\TpnC41C^JF02379

Species

D. melanogaster

Name

FlyBase ID

FBal0220743

Feature type

allele

Associated gene

Dmel\TpnC41C

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02379}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02379}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02379

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4¹¹⁵¹

(Chechenova et al., 2017)

abnormal flight, with Scer\GAL4^Hk-UH3

(Singh et al., 2014)

abnormal jump response, with Scer\GAL4^Act79B.PB

(Chechenova et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of TpnC41C^JF02379 results in decreased jumping ability (with the Scer\GAL4^Act79B.PB driver) and moderately increased number of flies that fly abnormally (downward) is observed but the majority of them (close to 70%) does not display any flight defects (with the Scer\GAL4¹¹⁵¹ driver).

(Chechenova et al., 2017)

Walking and jumping behaviors are unaffected in flies expressing TpnC41C^JF02379 under the control of Scer\GAL4^Hk-UH3 (limited to the late stages of development using Scer\GAL80^ts.αTub84B). Indirect flight muscle fascicles appear completely normal.

(Singh et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Act79B.PB, TpnC41C^JF02379 has abnormal jump response phenotype, enhanceable by TpnC4^KK110436/Scer\GAL4^Act88F.PB/Scer\GAL4^Act79B.PB

(Chechenova et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Act88F.PB, TpnC41C^JF02379, Scer\GAL4^Act79B.PB is an enhancer of abnormal jump response phenotype of Scer\GAL4^Act79B.PB, TpnC4^KK110436

(Chechenova et al., 2017)

Other

Statement

Reference

Scer\GAL4^Act79B.PB, Scer\GAL4^Act88F.PB, TpnC41C^JF02379, TpnC4^KK110436 has abnormal flight phenotype

(Chechenova et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Adult flies expressing both TpnC41C^JF02379 and TpnC4^KK110436 simultaneously under the combined control of Scer\GAL4^Act79B.PB and Scer\GAL4^Act88F.PB cannot jump and display severe flight defects with the majority of animals being completely flightless.

(Chechenova et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27053

y¹ v¹; P{TRiP.JF02379}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

TpnC41C^JF02379

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close